import ctypes class disable_file_system_redirection: _disable = ctypes.windll.kernel32.Wow64DisableWow64FsRedirection _revert = ctypes.windll.kernel32.Wow64RevertWow64FsRedirection def __enter__(self): self.old_value = ctypes.c_long() self.success = self._disable(ctypes.byref(self.old_value)) def __exit__(self, type, value, traceback): if self.success: self._revert(self.old_value) import subprocess path = 'C:\\Windows\\System32\\manage-bde.exe -status' with disable_file_system_redirection(): process = subprocess.Popen((path), shell=True, stdout=subprocess.PIPE) result = process.communicate()[0] print result