import os import ctypes path="HKLM\Software\Policies\Microsoft\Windows\WindowsUpdate\AU" #path of registry Key="UseWUServer" #key value class disable_file_system_redirection: _disable = ctypes.windll.kernel32.Wow64DisableWow64FsRedirection _revert = ctypes.windll.kernel32.Wow64RevertWow64FsRedirection def __enter__(self): self.old_value = ctypes.c_long() self.success = self._disable(ctypes.byref(self.old_value)) def __exit__(self, type, value, traceback): if self.success: self._revert(self.old_value) CMD=r'reg delete "%s\%s" /f'%(path,Key) with disable_file_system_redirection(): out=os.popen(CMD).read() print out if len(out): c=0 else: print "Registry path Doesn't exist"